Journal Articles

Haberman Y, Karns R, Dexheimer PJ, Schirmer M, Somekh J, Jurickova I, Braun T, Novak E, Bauman L, Collins MH, Mo A, Rosen MJ, Bonkowski E, Gotman N, Marquis A, Nistel M, Rufo PA, Baker SS, Sauer CG, Markowitz J, Pfefferkorn MD, Rosh JR, Boyle BM, Mack DR, Baldassano RN, Shah S, Leleiko NS, Heyman MB, Grifiths AM, Patel AS, Noe JD, Aronow BJ, Kugathasan S, Walters TD, Gibson G, Thomas SD, Mollen K, Shen-Orr S, Huttenhower C, Xavier RJ, Hyams JS, Denson LA. Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Nat Commun. 2019 Jan 3;10(1):38. doi: 10.1038/s41467-018-07841-3.

Krishnakumar C, Ballengee CR, Liu C, Kim MO, Baker SS, Baldassano RN, Cohen SA, Crandall WV, Denson LA, Dubinsky MC, Evans J, Gokhale R, Griffiths A, Guthery SL, Oliva-Hemker M, Heyman MB, Keljo D, Kellermayer R, Leleiko NS, Mack DR, Markowitz JF, Moulton DE, Noe JD, Otley AR, Patel AS, Pfefferkorn M, Rabizadeh S, Rosh JR, Snapper S, Walters TD, Ziring D, Mondal K, Kappelman MD, Hyams JS, Kugathasan S. Variation in Care in the Management of Children With Crohn's Disease: Data From a Multicenter Inception Cohort Study. Inflammatory Bowel Diseases. 2019 July; 25(7):1208-1217, doi:10.1093/ibd/izy363

Bismar N, Knod JL, Patel AS, Schindel DT. Outcomes following two-stage surgical approaches in the treatment of pediatric ulcerative colitis. J Pediatr Surg. 2018 Oct 22. pii: S0022-3468(18)30671-7. doi: 10.1016/j.jpedsurg.2018.09.021.

Schirmer M, Denson L, Vlamakis H, Franzosa EA, Thomas S, Gotman NM, Rufo P, Baker SS, Sauer C, Markowitz J, Pfefferkorn M, Oliva-Hemker M, Rosh J, Otley A, Boyle B, Mack D, Baldassano R, Keljo D, LeLeiko N, Heyman M, Griffiths A, Patel AS, Noe J, Kugathasan S, Walters T, Huttenhower C, Hyams J, Xavier RJ. Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course. Cell Host Microbe. 2018 Oct 10;24(4):600-610.e4. doi: 10.1016/j.chom.2018.09.009.

Lindoso L, Mondal K, Venkateswaran S, Somineni HK, Ballengee C, Walters TD, Griffiths A, Noe JD, Crandall W, Snapper S, Rabizadeh S, Rosh JR, LeLeiko N, Guthery S, Mack D, Kellermayer R, Gulati AS, Pfefferkorn MD, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley A, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Stephens MC, Baldassano R, Dubinsky MC, Markowitz J, Denson LA, Hyams J, Kugathasan S, Ananthakrishnan AN. The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn's Disease in Children. Am J Gastroenterol. 2018 Oct;113(10):1524-1529. doi: 10.1038/s41395-018-0239-9.

Spencer EA, Davis SM, Mack DR, Boyle BM, Griffiths AM, LeLeiko NS, Sauer CG, Keljo DJ, Markowitz JF, Baker SS, Rosh JR, Baldassano RN, Oliva-Hemker M, Pfefferkorn MD, Otley AR, Heyman MB, Noe JD, Patel AS, Rufo PA; PROTECT Study Group, Alison Marquis M, Walters TD, Collins MH, Kugathasan S, Denson LA, Hyams JS, Dubinsky MC. Serologic Reactivity Reflects Clinical Expression of Ulcerative Colitis in Children. Inflamm Bowel Dis. 2018 May 18;24(6):1335-1343. doi: 10.1093/ibd/izy009.

Venkateswaran S, Prince J, Cutler DJ, Marigorta UM, Okou DT, Prahalad S, Mack D, Boyle B, Walters T, Griffiths A, Sauer CG, LeLeiko N, Keljo D, Markowitz J, Baker SS, Rosh J, Pfefferkorn M, Heyman MB, Patel AS, Otley A, Baldassano R, Noe J, Rufo P, Oliva-Hemker M, Davis S, Zwick ME, Gibson G, Denson LA, Hyams J, Kugathasan S. Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis. Inflamm Bowel Dis. 2018 Mar 19;24(4):829-838.

Haberman Y, BenShoshan M, Di Segni A, Dexheimer PJ, Braun T, Weiss B, Walters TD, Baldassano RN, Noe JD, Markowitz J, Rosh J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Kellermayer R, Patel A, Otley A, Steiner SJ, Gulati AS, Guthery SL, LeLeiko N, Moulton D, Kirschner BS, Snapper S, Avivi C, Barshack I, Oliva-Hemker M, Cohen SA, Keljo DJ, Ziring D, Anikster Y, Aronow B, Hyams JS, Kugathasan S, Denson LA. Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease. Inflamm Bowel Dis. 2018 Jan 18;24(2):346-360.

Varni JW, Shulman RJ, Self MM, Saeed SA, Zacur GM, Patel AS, Nurko S, Neigut DA, Franciosi JP, Saps M, Denham JM, Dark CV, Bendo CB, Pohl JF; Pediatric Quality of Life Inventory Gastrointestinal Symptoms Module Testing Study Consortium. Perceived medication adherence barriers mediating effects between gastrointestinal symptoms and health-related quality of life in pediatric inflammatory bowel disease. Qual Life Res. 2018 Jan;27(1):195-204. doi: 10.1007/s11136-017-1702-6.

Varni JW, Shulman RJ, Self MM, Saeed SA, Patel AS, Nurko S, Neigut DA, Saps M, Zacur GM, Dark CV, Bendo CB, Pohl JF. Patient Health Communication Mediating Effects Between Gastrointestinal Symptoms and Gastrointestinal Worry in Pediatric Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017 May;23(5):704-711. doi: 10.1097/MIB.0000000000001077.

Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M, Mondal K, Liu C, Griffiths A, Noe JD, Crandall WV, Snapper S, Rabizadeh S, Rosh JR, Shapiro JM, Guthery S, Mack DR, Kellermayer R, Kappelman MD, Steiner S, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley AR, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Trapnell BC, Sylvester FA, Stephens MC, Baldassano RN, Markowitz JF, Cho J, Xavier RJ, Huttenhower C, Aronow BJ, Gibson G, Hyams JS, Dubinsky MC. Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study. Lancet. 2017 Apr 29;389(10080):1710-1718. doi: 10.1016/S0140-6736(17)30317-3.

Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, Chopra P, Prince J, Begum F, Kumar A, Huang C, Venkateswaran S, Datta LW, Wei Z, Thomas K, Herrinton LJ, Klapproth JA, Quiros AJ, Seminerio J, Liu Z, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Dryden GW, Hanson JS, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kirschner BS, Kuemmerle JF, Kwon JH, Lazarev M, Li E, Mack D, Mannon P, Moulton DE, Newberry RD, Osuntokun BO, Patel AS, Saeed SA, Targan SR, Valentine JF, Wang MH, Zonca M, Rioux JD, Duerr RH, Silverberg MS, Cho JH, Hakonarson H, Zwick ME, McGovern DP, Kugathasan S. Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. Gastroenterology. 2017 Jan;152(1):206-217.e2. doi: 10.1053/j.gastro.2016.09.032.

Varni, J.W., Shulman, R.J., Self, M.M., Nurko, S., Saps, M., Saeed, S., Patel, AS, Bendo, C.B., Dark, C.V., & Pohl, J.F. PedsQL Gastrointestinal symptoms predictors of health-related quality of life in pediatric patients with functional gastrointestinal disorders. Qual Life Res. 2017; 26: 1015-1025. doi:10.1007/s11136-016-1430-3.

Patel AS and Sifuentes-Dominguez L. Genetics and Therapeutics in Pediatric Ulcerative Colitis: the Past, Present and Future [version 1; peer review: 2 approved]. F1000Research 2016, 5(F1000 Faculty Rev):240 doi:10.12688/f1000research.7440.1.

Patel AS, Suarez LD & Rosh JR. Adalimumab in pediatric Crohn's disease. Immunotherapy. 2016 Feb; 8(2): 127-133. doi: 10.2217/IMT.15.114.

Varni JW, Shulman RJ, Self MM, Nurko S, Saps M, Saeed S, Bendo CB, Patel AS, Dark CV, Zacur GM, & Pohl JF. Symptom profiles in patients with irritable bowel syndrome or functional abdominal pain compared to healthy controls. Journal of Pediatric Gastroenterology and Nutrition: 2015 Sept; 61(3):323-329. doi: 10.1097/MPG.0000000000000795.

Varni JW, Bendo CB, Denham J, Shulman RJ, Self MM, Neigut DA, Nurko S, Patel AS, Franciosi JP, Saps M, Berga B, Smith A, Yeckes A, Heinz N, Langseder A, Saeed S, Zacur GM, Pohl JF. PedsQL Gastrointestinal Symptoms Module: Feasibility, Reliability, and Validity. Journal of Pediatric Gastroenterology and Nutrition. 2014 Sept;59(3):347-355. doi: 10.1097/MPG.0000000000000414

Varni JW, Bendo CB, Denham J, Shulman RJ, Self MM, Neigut DA, Nurko S, Patel AS, Franciosi JP, Saps M, Yeckes A, Langseder A, Saeed S, Pohl JF. PedsQL Gastrointestinal Symptoms Scales and Gastrointestinal Worry Scales in Pediatric Patients with Functional and Organic Gastrointestinal Diseases in Comparison to Health Controls. J Pediatr Psychol. 2015 Jul; 40(6): 591-601.doi: 10.1093/jpepsy/jsv005.

Forrest C, Crandall W, Bailey L, Zhang P, Joffe M, Colletti R, Alder J, Baron H, Berman F, Del Rosario F, Grossman A, Hoffenberg E, Israel E, Kim S, Lightdale J, Margolis P, Marsolo K, Mehta D, Milov D, Patel AS, Tung J, Kappelman M. Effectiveness of Anti-TNFa for Crohn Disease: Research in a Pediatric Learning Health System. Pediatrics. 2014 Jul; 134(1): 37-44. doi: 10.1542/peds.2013-4103.

Mitui M, Patel AS, Kristine Leos N, Doern C, Park J. Novel Helicobacter Pylori Sequencing Test Identifies High Rate of Clarithromycin Resistance. Journal of Pediatric Gastroenterology and Nutrition. 2014 Jul; 59 (1):6-9. doi: 10.1097/MPG.0000000000000380.

Stoll ML, Punaro M, Patel AS. MR enterography to evaluate sub-clinical intestinal inflammation in children with spondyloarthritis. Pediatric Rheumatology. 2012 10:6. doi: 10.1186/1546-0096-10-6.

Stoll ML, Punaro M, Patel AS. Fecal calprotectin in children with the enthesitis-related arthritis subtype of juvenile idiopathic arthritis. J Rheumatol. 2011 Oct; 38(10): 2274-5. doi: 10.3899/jrheum.110508.

Crandall W, Kappelman MD, Colletti RB, Leibowitz I, Grunow JE, Ali S, Baron HI, Berman JH, Boyle B, Cohen S, Del Rosario F, Denson LA, Duffy L, Integlia MJ, Kim SC, Milov D, Patel AS, Schoen BT, Walkiewicz D, Margolis P. ImproveCareNow: The development of a pediatric inflammatory bowel disease improvement network. Inflamm Bowel Dis. 2011 Jan; 17 (1): 450-7. doi: 10.1002/ibd.21394.

Long M, Crandall W, Leibowitz I, Duffy L, Rosario F, Kim S, Integlia M, Berman J, Grunow J, Grunow J, Colletti R, Schoen B, Patel AS, Baron H, Israel E, Russell G, Ali S, Herfarth H, Martin C, Kappelman M. The Prevalence and Epidemiology of Overweight and Obesity in Children with Inflammatory Bowel Disease. Inflamm Bowel Dis. 2011 Oct; 17(10): 2162-2168. doi: 10.1002/ibd.21585.

Rakheja D, Cunningham J, Mitui M, Patel AS, Weinberg AG. A Subset of Cranial Fasciitis is Associated with Dysregulation of APC/?-catenin Pathway. Mod Pathol. 2008 Nov; 21(11):1330-6. doi:10.1038/modpathol.2008.112.

Reviews, Chapters, Monographs and Editorials

Gurram B, Patel AS. Recent advances in understanding and managing pediatric inflammatory bowel disease. Accepted to F1000 Faculty Reviews

Sifuentes-Dominguez L, Patel AS. Review: Challenges in the area of IBD Patients of All Ages. Practical Gastroenterology. Dec.2014; 80.

Patel AS. Review: Grading and Staging in Gastroenterology. Practical Gastroenterology. 2009 April; 55-56.

Sathe MN, Patel AS. Update in pediatrics: focus on fat-soluble vitamins. Nutrition in clinical practice: official publication of the American Society for Parenteral and Enteral Nutrition, 2010 Aug; 25 (4):340-6.

Acute Pancreatitis. Patel AS, Barth B. Pediatric Gastroenterology Fellow's Handbook 2005.

Proton Pump Inhibitors and Pediatrics. Patel AS, Pohl J, Easley D: Pediatrics in Review. 2003; 24:12-15.

Case Reports

Hypercoagulation and Pediatric Inflammatory Bowel Disease: A Case Report. Ruan W, Shamoun M, Schindel D, Patel AS. J Pediatr Gastroenterol Nutr. 2018 Apr;66(4): e112-e114. doi: 10.1097/MPG.0000000000001884. PMID: 29287018.

Hypercoagulation and Pediatric Inflammatory Bowel Disease - A Case Report. Ruan W, Schindel D, Patel AS: poster presentation, World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada, Oct 2016.

Safety and Efficacy of Ferric Carboxylmaltose Iron Infusions in Children with Inflammatory Bowel Disease and Iron Deficiency Anemia. Luu P, Patel AS: poster presentation, World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada, Oct 2016.

The Impact of Obesity on the Natural History of Pediatric Inflammatory Bowel Disease. Odiase E, Patel AS: poster presentation, World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Montreal, Canada, Oct 2016.

Bowel Wall Thickening and Henoch Schonlein Purpura-An Atypical" Relationship. Ruan W, Kwon J, Patel AS: poster presentation, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Chicago, IL, Oct.2015.

Fidaxomicin: A New Treatment Option for Recurrent C. difficile Infection in Children. Luu P, Patel AS: poster presentation, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Chicago, IL, Oct.2015.

Center-perspective in Transitioning adolescents with Inflammatory Bowel Disease to Adult Care. Chan L, Patel AS: poster presentation, Digestive Disease Week, Orlando, FL, May 2013.

Anti TNF-[alpha] Induced Psoriasis in Children Treated for Inflammatory Bowel Disease. Nguyen N, Patel AS: poster presentation, Pediatric Academic Societies' Annual Meeting, Washington, DC, May 2013.

Ileocecal Lymphoma Presenting as Small Bowel Obstruction. Troendle D, Patel AS: poster presentation, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual National Meeting, Salt Lake City, UT, 2012.

The Association of Lymphocytic Esophagitis with Pediatric Crohn's Disease. Heintz D, Patel AS: poster presentation, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual National Meeting, Salt Lake City, UT, 2012.

Growth Failure in a Pediatric Inflammatory Bowel Disease Registry (PIBDNet) with Specific Association to Disease Phenotype. Patel AS. poster presentation, World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Iguassu Falls, Brazil, August 2008.

Increased Protein Catabolism Correlates with Increased Disease Activity in Children with Crohn's Disease. Patel AS, Andersen JM, Hardin D: poster presentation, Digestive Disease Week, Los Angeles, CA, 2006.

Novel Association Between Tumor Necrosis Factor Super Family 15 (TNFSF15) and Disease Phenotype in Early-Onset Crohn's Disease. Dubinsky, Marla, Picornell, Yoana, Patel AS, Wang, Dai, Wrobel, Iwona, Wahbeh, Ghassan, Quiros, Antonio, Silber, Gary, Katzir, Lirona, Vasiliauskas, Eric, Grill, Bruce, Rotter, Jerome. J Pediatr Gastroenterol Nutr 2006; 43(4):e33. Received Young Clinical Investigator Award.

Serum Sickness Following Infliximab. Patel AS, Andersen JM: poster presentation, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual National Meeting, Orlando, FL, 2006.

Crohn's Disease Presenting with Pyogenic Abscess in Childhood. Patel AS, Rodriguez-Baez N: poster presentation, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual National Meeting, Orlando, FL, 2006.

Retrospective Review of Pediatric Magnetic Resonance Cholangiography Usage at Scott and White Hospital. Patel AS, Easley D, Pohl J: 2003, retrospective review presented at Myers Lectureship in Pediatrics, 2003.

Clinical Practice Guidelines

Benkov K, Lu Y, Patel AS, Rahhal R, Russell G, Teitelbaum J, NASPGHAN Committee on Inflammatory Bowel Disease. Role of Thiopurine Metabolite Testing and Thiopurine Methyltransferase Determination in Pediatric IBD. J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):333-40.

Kappelman MD, Crandall WV, Colletti RB, Goudie A, Leibowitz IH, Duffy L, Milov DE, Kim SC, Schoen BT, Patel AS, Grunow J, Larry E, Fairbrother G, Margolis P. Short pediatric Crohn's disease activity index for quality improvement and observational research. Inflamm Bowel Dis. 2011 Jan; 17 (1):112-7.

Crandall W, Kappelman M, Colletti R, Denson L, Duffy L, Grunow J, Kim S, Leibowitz I, Patel AS, Schoen B, Tomer G, Milov D, Cohen S, Margolis P. Outcomes in a Quality Improvement Collaborative for Pediatric Ulcerative Colitis. Gastro Vol 138 (5, Suppl 1) May 2010, S-29.

Patel AS, Kim S, Kappelman M, Colletti R, Cohen S, Grunow J, Crandall W, Duffy L, Gold B, Leibowitz I, Margolis P, Mehta D, Milov D, Moyer S, Myers S, Schoen B, Sudel B, Bornstein J. Growth failure in a pediatric inflammatory bowel disease registry (PIBDNet) with specific association to disease phenotype. J Pediatr Gastroenterol Nutr [JPGN web site].

Crandall W, Kappelman M, Colletti RB, Denson L, Duffy L, Grunow J, Kim S, Leibowitz I, Patel AS, Schoen B, Tomer G, Milov D, Cohen S, Margolis P, and the ImproveCareNow Collaborative (formerly PIBDNet). Increased remission in a quality improvement collaborative for pediatric Crohn disease. Gastroenterol 2009;135 (49) Suppl 1 :E60.

Kappelman M, Goudie A, Crandall W, Larry E, Fairbrother G, Margolis P, Leibowitz I, Duffy L, Milov D, Kim S, Schoen B, Cohen S, Patel AS, Grunow J, Colletti R. A Rapid Pediatric Crohn's Disease Activity Index for Quality Improvement and Observational Research. J Pediatr Gastroenterol Nutr 2009; 196 (49) Suppl 1:E87.

Kappelman MD, Cohen SA, Crandall W, Duffy LF, Gold BD, Grunow J, Kim SC, Leibowitz I, Margolis P, Mehta DI, Milov DE, Moyer MS, Myers SK, Patel AS, Schoen BT, Sudel B, Colletti RB. Accelerating improvement in the management of pediatric inflammatory bowel disease. Gastroenterol 2008;134(S1):A473.

Kappelman MD, Cohen SA, Crandall W, Duffy L, Gold BD, Grunow J, Kim SC, Leibowitz I, Margolis PA, Mehta DI, Milov DE, Moyer MS, Myers S, Patel AS, Schoen B, Sudel B, Bornstein JA, Colletti RB. Improving care of pediatric inflammatory bowel disease: preliminary results of a multicenter improvement collaborative. Presented at the Pediatric Academic Societies Annual Meeting, Honolulu HI, May 2008. E-PAS2008:5625.

Kappelman, M, Margolis, P, Moyer M, Cohen S, Gold B, Crandall W, Patel AS, Mehta D, Milov D, Grunow J, Leibowitza I, Colletti R. The Quality of Care in Pediatric Inflammatory Bowel Disease: Does the Chronic Care Model work? J Pediatr Gastroenterol Nutr 2007; 45 E5.

Improving Care of Pediatric Inflammatory Bowel Disease: Preliminary Results of a Multicenter Improvement Collaborative. Kappelman M, Cohen S, Crandall W, Duffy L, Gold B, Grunow J, Kim S, Leibowitz I, Margolis P, Mehta D, Milov D, Moyer S, Myers S, Patel AS, Schoen B, Sudel B, Bornstein JA, Colletti R. Pediatric Academic Societies' & Asian Society for Pediatric Research Joint Meeting, Honolulu, HI 2008.

The quality of care in pediatric inflammatory bowel disease: does the chronic care model work? Kappelman M, Margolis P, Moyer M, Cohen S, Gold B, Crandall W, Patel AS, Mehta D, Milov D, Grunow J, Leibowitz I, Colletti R. J Pediatr Gastroenterol Nutr 2007;45:e5.

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