About Brian L. Appavu, MD

Dr. Brian Appavu is an assistant professor of neurology and child health at the University of Arizona College of Medicine, and an ICU neurologist and epileptologist at Phoenix Children's Hospital. He is one of an extremely select group of neurologists in the country who are board-certified in child neurology, epilepsy and neurosonology. Dr. Appavu champions the utilization of advanced physiologic techniques such as continuous electroencephalography and transcranial doppler ultrasound to provide advanced physiologic multimodal neuromonitoring and deliver the best neurologic care for critically ill children.

Dr. Appavu is also passionate about pediatric neurocritical care education, providing monthly educational lectures to residents and fellows and running an advanced nursing neurocritical care course. Dr. Appavu was voted by the Barrow Neurological Institute residents as the 2018 Child Neurology Teacher of the Year.

Dr. Appavu grew up in the suburbs of Chicago, IL and received his Bachelor of Science in biochemistry at the University of Illinois at Chicago. He received his medical degree at Medical College of Wisconsin and did his child neurology residency at the Barrow Neurological Institute at Phoenix Children's Hospital. He completed a clinical neurophysiology fellowship at Columbia University Medical Center in New York.

Dr. Appavu currently lives in Mesa, AZ with his wife Michelle who is an English professor and author, and their Portuguese water dog, Fawkes. Outside of work, Dr. Appavu enjoys hiking in the East Valley and jazz drumming.

Medical School / Education

Medical College of Wisconsin, Milwaukee, WI


Phoenix Children's Hospital, Phoenix, AZ


(Child Neurology) Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ


(Clinical Neurophysiology) Columbia University Medical Center, New York, NY

Neurology with Special Qualification in Child Neurology, Subspecialty-Epilepsy, Neurocritical Care

American Board of Psychiatry & Neurology

Pediatric Neurocritical Care


ICU EEG Monitoring

ICU Multimodal Monitoring


Pediatric Stroke

Academic Affiliations

Clinical Assistant Professor of Neurology and Child Health, University of Arizona College of Medicine

Professional Affiliations

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">Child Neurology Society

Neurocritical Care Society

American Epilepsy Society

American Academy of Neurology

American Society of Neuroimaging"


Appavu B, Riviello JJR. Electroencephalographic Patterns in Neurocritical Care - Pathologic Contributors or Epiphenomena? Neurocritical Care. 2018 Aug; 29(1):9-19. PMID: 28660340

Appavu B, Fox J, Little R, Kerrigan JF, Obeid M. Seizures Induced by Exiting Water: A Unique Form of Reflex Epilepsy. Neurologist. 2017 Sep 22. PMID 28859025

Appavu B, Guido-Estrada N, Lindstrom K, Grebe T, Kerrigan JF, Troester M. Electroclinical Phenotypes and Outcomes in TBC1D24-Related Epilepsy. Epileptic Disorders. 2016 Aug 8. PMID: 27502353

Appavu B, Vanatta L, Condie J, Kerrigan J, Jarrar R. Ketogenic Diet Treatment for Pediatric Super-Refractory Status Epilepticus. Seizure. 2016 Oct;41:62-65. PMID: 27475280

Appavu B, Ashby D, Condie J. Manifestation of West Nile Encephalitis in Infancy. J Pediatric Infect Dis Soc. 2015 Dec;4(4):e166-8. PMID: 26501475

Appavu B, Mangum T, Obeid M. Glucose 1 Transporter Deficiency: a Treatable Cause of Epileptic Myoclonus. Pediatric Neurology. 2015 Oct;53(4):364-6. PMID: 26385057

Arsenieva D, Appavu BL, Mazock GH, Jeffery CJ. Crystal structure of phosphoglucose isomearse from Trypanosoma brucei complexed with glucose-6-phosphate at 1.6 A resolution. Proteins. 2009 Jan;74(1):72-80. PMID: 18561188


Appavu B (2018) Electroencephalographic Patterns in Neurocritical Care. Brain Matters Lecture Series. URL: https://www.youtube.com/watch?v=_9y3F2dym5k&t=1298s


Phoenix Children's Hospital - Thomas Campus

1919 E. Thomas Rd.
Phoenix, AZ 85016

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Dr Appavu was very kind and professional on the call. He listened to my daughter's concerns and answered our questions in a polite manner. He is a fantastic provider in neurology. thank you for having him on this team.

Dr Appavu makes me feel comforted by remembering Kirsten's Epilepsy history and does not seem rushed. That is greatly appreciated.