About Mitchell D. Shub, MD
Mitchell Shub, MD, grew up with a younger brother who had Down syndrome and uncorrectable congenital heart disease. This experience helped him understand the toll a child's special needs and serious medical conditions can have on a family. The experience inspired him to pursue a career in pediatric medicine.
"I wanted to be able to help children like my brother," says Dr. Shub, a pediatric gastroenterologist with over 40 years of practice experience. "I love caring for children and improving their quality of life."
Another young patient stirred Dr. Shub's interest in gastroenterology. As a first-year resident at Duke University, Dr. Shub was caring for a hospitalized child with severe Crohn's disease. At the time, he recalls, there were few pediatric gastroenterologists in the country and none in North Carolina. Dr. Shub connected with a pediatric gastroenterologist at UCLA who helped him treat the patient. The patient soon recovered and went home from the hospital.
"Ever since that experience, I was hooked on being a gastroenterologist," says Dr. Shub, former chief of Phoenix Children's Division of Pediatric Gastroenterology and past president of the hospital's medical staff.
Committed to providing family-centered care tailored to each child's unique needs, Dr. Shub also has been engaged in clinical research throughout his career, with his recent primary focus on a rare cause of congenital diarrhea. This work, which involved collaboration with scientists at the University of Arizona and Vanderbilt University, resulted in the discovery of the genetic cause for this disease and ultimately will lead to better treatments.
Dr. Shub, who joined Phoenix Children's in 1985, has also devoted his expertise to training future pediatric doctors. A founding member of the University of Arizona College of Medicine-Phoenix, he served for seven years as chair of the Department of Child Health. Dr. Shub was honored to give the school's commencement address in 2018, marking the 10th anniversary of its founding.
Outside of work, Dr. Shub looks forward to visiting his grandchildren every weekend over FaceTime. He also enjoys playing golf with his wife, reading medical literature outside of his field and keeping in touch via Zoom with a longtime group of pediatric GI friends.
Medical School / Education
University of Vermont College of Medicine, Burlington, VT
Residency
(Pediatrics) Duke University Medical Center, Durham, NC
Fellowship
(Pediatric Gastroenterology and Nutrition) Massachusetts General Hospital and Harvard Medical School, Cambridge, MA
Pediatrics, Subspecialty-Pediatric Gastroenterology
American Board of Pediatrics
Gastroenterology
Hepatology
Nutrition
Pediatrics
Inflammatory Bowel Disease
Microvillous Atrophy
Gastric Reflux Disorders
Academic Affiliations
Professor, Clinical Pediatrics, University of Arizona College of Medicine - Phoenix
Executive Chair, Department of Health, University of Arizona College of Medicine - Phoenix
Associate Head, Department of Pediatrics, University of Arizona College of Medicine - Phoenix
Professional Affiliations
Fellow, American Academy of Pediatrics
Phoenix Pediatric Society
American Academy of Pediatrics
Gastroenterology Research Group
Western Society for Pediatric Research
American Gastroenterology Association
American Society for Gastrointestinal Endosurgery
North American Society of Pediatric Gastroenterology, Hepatology and Nutrition
BOOKS
Contributor to Benkov, K. and Winter, H. Managing Your Child's Crohn's Disease or Ulcerative Colitis, New York, Mastermedia Limited. 1996.
Shub, M.D. Section Editor, Section VIII: Gastroenterology. In Perkin, R. M., Swift, J.D. and Newton, D. (eds.) Pediatric Hospital Medicine, Philadelphia, Lippincott, Williams, and Wilkins, pp 327-362, 2003.
Shub, M.D., Walker, W.A. Intractable diarrhea of infancy. In Gellis S.S. and Kagan B.M. (eds.) Current Pediatric Therapy. Vol. 10, Philadelphia, Saunder's Co., pp 174-175, 1982.
Ulshen, M.H., Shub, M.D. Chronic diarrhea and malabsorption syndromes. In Gellis S.S. and Kagan B.M. (eds.) Current Pediatric Therapy, Vol. 13, Philadelphia, W.B. Saunders Co., pp 222-225, 1990.
Ulshen, M.H., Shub, M.D. Protracted diarrhea of infancy. In Gellis S.S. and Kagan B.M. (eds.) Current Pediatric Therapy, Vol. 13 Philadelphia, W.B. Saunders Co., pp 186-187, 1990.
Shub, M.D. Esophageal Disorders, Gastroesophageal Reflux Disease. In Perkin, R.M., Swift, J.D. and Newton, D. (eds.) Pediatric Hospital Medicine, Philadelphia, Lippincott, Williams, and Wilkins, pp 341-344, 2003.
Rayhorn, N.J., Shub M.D., Inflammatory Bowel Disease. In Perkin, R.M., Swift, J.D. and Newton, D. (eds.) Pediatric Hospital Medicine, Philadelphia, Lippincott, Williams, and Wilkins, pp 345-351, 2003.
Shub, M. D. Esophageal Burns. In Pohl, J., Jolley, C. D. and Gelfond, D. (eds.). Pediatric Gastroenterology - A color Handbook, CRC Press, Taylor & Francis Group, LLC, pp 105-113, 2014.
JOURNAL ARTICLES
Shub, M.D., Pang, K.Y., Swann, D.A., Walker, W.A. Age-Related Changes in Chemical Composition and Physical Properties of Mucus Glycoprotein's from Rat Small Intestines. Biochem. J. 215:405-411, 1983.
Hargrove, C.B., Ulshen, M.H., Shub, M.D. Upper Gastrointestinal Endoscopy in Infants: Diagnostic Usefulness and Safety. Pediatrics 74:828-831, 1984.
Shub, M.D., Ulshen, M.H., Hargrove, C.B., Siegal G.P., Groben P.A., Askin, F.B. Esophagitis: A Frequent Consequence of Gastroesophageal Reflux in Infancy. J. Pediatr. 107:881-884, 1985.
Groben, P.A., Siegal, G.P., Shub, M.D., Ulshen, M.H., Askin, F.B. Gastroesophageal Reflux and Esophagitis in Infants and Children. Perspect. Pediatr. Pathol. 11:124-151, 1987.
Ingebo, K.R., Rayhorn, N.J., Hecht, R.M., Shelton, M.T., Silber, G.H., Shub, M.D. Safe Sedation for Children: Adequacy of Two-hour Fasting. J. Pediatr., 131:155-158, 1997.
Drewitz, D.J., Shub, M.D., Ramirez, F.C. Gastrospirillum Hominis Gastritis in a Child with Celiac Sprue. Digestive Diseases and Science 42:1083-1086, 1997.
Pohl, J.F., Shub, M.D., Trevelline, E.E., Ingebo, K.R., Silber, G.H., Rayhorn, N., Holve, S., Hu, D. A Cluster of Microvillous Inclusion Disease in the Navajo Population. J. Pediatr. 134:103-106, 1999.
Holve, S., Hu, D., Shub, M., Tyson, R.W., Sokol, R.J. Liver Disease in NavajoNeuropathy.J.Pediatr.135:482-493,1999.
El-Serag, H.B., Gilger, M.A., Shub, M.D., Richardson, P., Bancroft, J., The Prevalence of Suspected Barrett's Esophagus in Children and Adolescents: A Multicenter Endoscopic Study. Gastrointest Endosc 64:671-5 2006.
Koslap-Petraco, M., Shub, M., Judelsohn, R. Hepatitis A: Disease Burden and Current Childhood Vaccination Strategies in the United States. J Pediatr Health Care. 22:3-11, 2008.
Gilger, M.A., El-Serag, H.B., Gold, B.D., Dietrich, C.L., Tsou, V.M., McDuffie, A., Shub, M.D. Prevalence of Endoscopic Findings of Erosive Esophagitis in Children: A Population Based Study. J. Pediatric Gastroenterol. Nutr. 47:141-146, 2008.
Erickson, R.P., Larson-Thome, K., Valenzuela, R.K., Whitaker, S.E., Shub, M.D., Navajo Microvillous Inclusion Disease is Due to a Mutation in MYO5B. Am J Med Genet. A 146A:3117-3119, 2008.
Nguyen, D.M., El-Serag, H.B., Shub, M., Integlia, M., Henderson, L., Richardson, P., Fairly, K., Gilger, M.A, Barrett's Esophagus in Children and Adolescents without Neurodevelopmental or Tracheoesophageal Abnormalities: a Prospective Study. Gastrointest Endosc 73:875-880, 2011.
Galloway, D., Pasternak B., Garg S., Shub, M., Multiple Duodenal Ulcers: An Unexpected Finding in Celiac Disease. J. Pediatric Gastroenterol. Nutr 2013 Apr; 56(4):e21 (4), DOI: 10.1097/MPG.0b013e31825040dd.
Oatman, O., Djedjos, C., Olson, M., Shub, M., Diabetes in Microvillous Inclusion Disease. J. Pediatric Gastroenerol. Nutr. 2014Dec;59(6):e50-1. doi: 10.1097/MPG.0b013e3182999b4f.
Knowles, B., Roland, J., Krishnan, M., Tyska, M., Lapierre, L., Dickman, P., Goldenring, J., Shub, M., MYO5B Uncoupling from Rab8a and Rab11a Elicits Microvillus Inclusion Disease. J. Clin. Invest. 124(7):2947-2962, 2014.
Knowles, B.C., Yu, S., Roland, J.T., Williams, J.A., Alvarado, G.S., Lapierre, L.A., Shub, M.D., Gao, N. and Goldenring, J.R., Rab11a Regulates Syntaxin 3 Trafficking and Microvillus Assembly in Enterocytes. J. Cell Sci 128:1617-1626, 2015. DOI:10.1242/JCS. 163303.
Shub, M., Therapy of Caustic Ingestions. New Treatment Considerations. Curr Opin Pediatr 27(5):609-613, 2015.
Thakkar, K., Holub, J. L., Gilger, M. A., Shub, M. D., McOmber, M., Tsou, M., Fishman, D.S., Quality Indicators for Pediatric Colonoscopy: Results from a Multi-center Consortium. Gastrointest Endosc 83(3): 533-541. 2016. doi: 10.1016/j.gie.2015.06.028. Epub 2015 Aug 5.
Miloh, T., Shub, M., Montes, R., Ingebo, K., Silber, G., Pasternak, B. Text Messaging Effect on Adherence in Children with Inflammatory Bowel Disease. J. Pediatric Gastroenerol. Nutr. 64: 939-942, 2017. DOI:10.1097/MPG.0000000000001399.
Schlegel, C., Weis, V., Knowles, B., Lapierre, L., Martin, M., Dickman, P., Goldenring, J.R., and Shub, M. Apical membrane alterations in non-intestinal organs in Microvillus Inclusion Disease. Dig. Dis. Sci. 63: 356-365, 2018. doi: 10.1007/s10620-017-4867-5 Epub 2017 Dec 7.
Engevik, A. C., Kaji, I., Engevik, M.A., Meyer, A.R., Weis, V.G., Hess, M. W., Koepsell, H., Tyska, M., Huber, L.A., Shub, M.D., Ameen, N., Goldenring, J. R. Loss of MYO5B Leads to Reductions in N+ Aborption with Maintenance of CFTR-dependent Cl- Secretion in Enterocytes. Gastroenterology 155: 1863-1897, 2018.
ON-LINE PUBLICATIONS AND ENDURING MATERIALS
Flores, S., Carter, J., Silber, G., Shub, M., Timmons, Z., Kelleher, K., Librizzi, J., Morse, K. PCH/PCCN Functional Constipation Pathway. (Clinical Pathway - Educational Resource), 2018.
Rating & Reviews
Dr Shub is a very experienced and knowledgeable doctor, and he is very compassionate and understanding for the Complicated medical issues that my son is facing and that I face as his caretaker. I feel very supported with his team in our corner.
Dr. Shun is always so attentive and truly cares about his patients. He is by far the best doctor my son has been seen by.
Dr Shub seems wonderful, careful, strategic, trustworthy, and very knowledgeable.
The Dr.. was very professional and understanding of my daughter situation,
I had an excellent experience with Dr. Mitchell Shub at Phoenix Children's Gastroenterology. He took the time to thoroughly answer every question we had regarding my son's health concerns. Dr. Shub provided a detailed explanation of my son's reflux issues and his challenges with weight gain, which was incredibly reassuring. His approach was both professional and compassionate, making us feel well-informed and supported throughout our consultation. I would definitely recommend Dr. Shub to my friends and family for anyone in need of a knowledgeable and caring pediatric gastroenterologist.