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Mitchell D. Shub, MD

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Mitchell D. Shub, MD

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Areas of Expertise

  • Gastroenterology; Hepatology; Nutrition; Pediatrics; Inflammatory Bowel Disease; Microvillous Atrophy; Gastric Reflux Disorders

+Education & Training

Board Certification

Pediatric Gastroenterology; General Pediatrics

Medical School / Education

University of Vermont College of Medicine, Burlington, VT


Duke University Medical Center, Durham, NC (Pediatrics)


Massachusetts General Hospital and Harvard Medical School, Cambridge, MA(Pediatric Gastroenterology and Nutrition)

+Academic and Professional Affiliations

Academic Affiliations

Executive Chair, Department of Health University of Arizona College of Medicine, Phoenix, AZ; Associate Head, Department of Pediatrics and Professor of Clinical Pediatrics at the University of Arizona College of Medicine, Tucson, AZ

Professional Affiliations

North American Society of Pediatric Gastroenterology, Hepatology and Nutrition; Fellow, American Academy of Pediatrics; American Gastroenterology Association; American Society for Gastrointestinal Endosurgery: Gastroenterology Research Group; Phoenix Pediatric Society; Western Society for Pediatric Research; American Academy of Pediatrics

+Research & Publications


Contributor to Benkov, K. and Winter, H. Managing Your Child's Crohn's Disease or Ulcerative Colitis, New York, Mastermedia Limited. 1996.

Shub, M.D. Section Editor, Section VIII: Gastroenterology. In Perkin, R. M., Swift, J.D. and Newton, D. (eds.) Pediatric Hospital Medicine, Philadelphia, Lippincott, Williams, and Wilkins, pp 327-362, 2003.

Shub, M.D., Walker, W.A. Intractable diarrhea of infancy. In Gellis S.S. and Kagan B.M. (eds.) Current Pediatric Therapy. Vol. 10, Philadelphia, Saunder's Co., pp 174-175, 1982.

Ulshen, M.H., Shub, M.D. Chronic diarrhea and malabsorption syndromes. In Gellis S.S. and Kagan B.M. (eds.) Current Pediatric Therapy, Vol. 13, Philadelphia, W.B. Saunders Co., pp 222-225, 1990.

Ulshen, M.H., Shub, M.D. Protracted diarrhea of infancy. In Gellis S.S. and Kagan B.M. (eds.) Current Pediatric Therapy, Vol. 13 Philadelphia, W.B. Saunders Co., pp 186-187, 1990.

Shub, M.D. Esophageal Disorders, Gastroesophageal Reflux Disease. In Perkin, R.M., Swift, J.D. and Newton, D. (eds.) Pediatric Hospital Medicine, Philadelphia, Lippincott, Williams, and Wilkins, pp 341-344, 2003.

Rayhorn, N.J., Shub M.D., Inflammatory Bowel Disease. In Perkin, R.M., Swift, J.D. and Newton, D. (eds.) Pediatric Hospital Medicine, Philadelphia, Lippincott, Williams, and Wilkins, pp 345-351, 2003.

Shub, M. D. Esophageal Burns. In Pohl, J., Jolley, C. D. and Gelfond, D. (eds.). Pediatric Gastroenterology - A color Handbook, CRC Press, Taylor & Francis Group, LLC, pp 105-113, 2014.

Journal Articles

Shub, M.D. Pang, K.Y., Swann, D.A., Walker, W.A. Age-Related Changes in Chemical Composition and Physical Properties of Mucus Glycoprotein's from Rat Small Intestines. Biochem. J. 215:405-411, 1983.

Hargrove, C.B., Ulshen, M.H., Shub, M.D. Upper Gastrointestinal Endoscopy in Infants: Diagnostic Usefulness and Safety. Pediatrics 74:828-831, 1984.

Shub, M.D., Ulshen, M.H., Hargrove, C.B., Siegal G.P., Groben P.A., Askin, F.B. Esophagitis: A Frequent Consequence of Gastroesophageal Reflux in Infancy. J. Pediatr. 107:881-884, 1985.

Groben, P.A., Siegal, G.P. Shub, M.D., Ulshen, M.H., Askin, F.B. Gastroesophageal Reflux and Esophagitis in Infants and Children. Perspect. Pediatr. Pathol. 11:124-151, 1987.

Ingebo, K.R., Rayhorn, N.J., Hecht, R.M., Shelton, M.T., Silber, G.H., Shub, M.D. Safe Sedation for Children: Adequacy of Two-hour Fasting. J. Pediatr., 131:155-158, 1997.

Drewitz, D.J., Shub, M.D., Ramirez, F.C. Gastrospirillum Hominis Gastritis in a Child with Celiac Sprue. Digestive Diseases and Science 42:1083-1086, 1997.

Pohl, J.F., Shub, M.D., Trevelline, E.E., Ingebo, K.R., Silber, G.H., Rayhorn, N., Holve, S., Hu, D. A Cluster of Microvillous Inclusion Disease in the Navajo Population. J. Pediatr. 134:103-106, 1999.

Holve, S., Hu, D., Shub, M., Tyson, R.W., Sokol, R.J. Liver Disease in NavajoNeuropathy.J.Pediatr.135:482-493,1999.

El-Serag, H.B., Gilger, M.A., Shub, M.D., Richardson, P., Bancroft, J., The Prevalence of Suspected Barrett's Esophagus in Children and Adolescents: A Multicenter Endoscopic Study. Gastrointest Endosc 64:671-5 2006.

Koslap-Petraco, M., Shub, M., Judelsohn, R. Hepatitis A: Disease Burden and Current Childhood Vaccination Strategies in the United States. J Pediatr Health Care. 22:3-11, 2008.

Gilger, M.A., El-Serag, H.B., Gold, B.D., Dietrich, C.L., Tsou, V.M., McDuffie, A., Shub, M.D. Prevalence of Endoscopic Findings of Erosive Esophagitis in Children: A Population Based Study. J. Pediatric Gastroenterol. Nutr. 47:141-146, 2008.

Erickson, R.P., Larson-Thome, K., Valenzuela, R.K., Whitaker, S.E., Shub, M.D., Navajo Microvillous Inclusion Disease is Due to a Mutation in MYO5B. Am J Med Genet. A 146A:3117-3119, 2008.

Nguyen, D.M., El-Serag, H.B., Shub, M., Integlia, M., Henderson, L., Richardson, P., Fairly, K., Gilger, M.A, Barrett's Esophagus in Children and Adolescents without Neurodevelopmental or Tracheoesophageal Abnormalities: a Prospective Study. Gastrointest Endosc 73:875-880, 2011.

Galloway, D., Pasternak B., Garg S., Shub, M., Multiple Duodenal Ulcers: An Unexpected Finding in Celiac Disease. J. Pediatric Gastroenterol. Nutr 2013 Apr; 56(4):e21 (4), DOI: 10.1097/MPG.0b013e31825040dd.

Oatman, O., Djedjos, C., Olson, M., Shub, M., Diabetes in Microvillous Inclusion Disease. J. Pediatric Gastroenerol. Nutr. 2014Dec;59(6):e50-1. doi: 10.1097/MPG.0b013e3182999b4f.

Knowles, B., Roland, J., Krishnan, M., Tyska, M., Lapierre, L., Dickman, P., Goldenring, J., Shub, M., MYO5B Uncoupling from Rab8a and Rab11a Elicits Microvillus Inclusion Disease. J. Clin. Invest. 124(7):2947-2962, 2014.

Knowles, B.C., Yu, S., Roland, J.T., Williams, J.A., Alvarado, G.S., Lapierre, L.A., Shub, M.D., Gao, N. and Goldenring, J.R., Rab11a Regulates Syntaxin 3 Trafficking and Microvillus Assembly in Enterocytes. J. Cell Sci 128:1617-1626, 2015. DOI:10.1242/JCS. 163303.

Shub, M., Therapy of Caustic Ingestions. New Treatment Considerations. Curr Opin Pediatr 27(5):609-613, 2015.

Thakkar, K., Holub, J. L., Gilger, M. A., Shub, M. D., McOmber, M., Tsou, M., Fishman, D.S., Quality Indicators for Pediatric Colonoscopy: Results from a Multi-center Consortium. Gastrointest Endosc 83(3): 533-541. 2016. doi: 10.1016/j.gie.2015.06.028. Epub 2015 Aug 5.

Miloh, T., Shub, M., Montes, R., Ingebo, K., Silber, G., Pasternak, B. Text Messaging Effect on Adherence in Children with Inflammatory Bowel Disease. J. Pediatric Gastroenerol. Nutr. 64: 939-942, 2017. DOI:10.1097/MPG.0000000000001399.

Schlegel, C., Weis, V., Knowles, B., Lapierre, L., Martin, M., Dickman, P., Goldenring, J.R., and Shub, M. Apical membrane alterations in non-intestinal organs in Microvillus Inclusion Disease. Dig. Dis. Sci. 63: 356-365, 2018. doi: 10.1007/s10620-017-4867-5 Epub 2017 Dec 7.

Engevik, A. C., Kaji, I., Engevik, M.A., Meyer, A.R., Weis, V.G., Hess, M. W., Koepsell, H., Tyska, M., Huber, L.A., Shub, M.D., Ameen, N., Goldenring, J. R. Loss of MYO5B Leads to Reductions in N+ Aborption with Maintenance of CFTR-dependent Cl- Secretion in Enterocytes. Gastroenterology 155: 1863-1897, 2018.

On-line Publications and Enduring Materials

Flores, S., Carter, J., Silber, G., Shub, M., Timmons, Z., Kelleher, K., Librizzi, J., Morse, K. PCH/PCCN Functional Constipation Pathway. (Clinical Pathway - Educational Resource), 2018.

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