About Mitchell D. Shub, MD
Mitchell Shub, MD, grew up with a younger brother who had Down syndrome and uncorrectable congenital heart disease. This experience helped him understand the toll a child's special needs and serious medical conditions can have on a family. The experience inspired him to pursue a career in pediatric medicine.
"I wanted to be able to help children like my brother," says Dr. Shub, a pediatric gastroenterologist with over 40 years of practice experience. "I love caring for children and improving their quality of life."
Another young patient stirred Dr. Shub's interest in gastroenterology. As a first-year resident at Duke University, Dr. Shub was caring for a hospitalized child with severe Crohn's disease. At the time, he recalls, there were few pediatric gastroenterologists in the country and none in North Carolina. Dr. Shub connected with a pediatric gastroenterologist at UCLA who helped him treat the patient. The patient soon recovered and went home from the hospital.
"Ever since that experience, I was hooked on being a gastroenterologist," says Dr. Shub, former chief of Phoenix Children's Division of Pediatric Gastroenterology and past president of the hospital's medical staff.
Committed to providing family-centered care tailored to each child's unique needs, Dr. Shub also has been engaged in clinical research throughout his career, with his recent primary focus on a rare cause of congenital diarrhea. This work, which involved collaboration with scientists at the University of Arizona and Vanderbilt University, resulted in the discovery of the genetic cause for this disease and ultimately will lead to better treatments.
Dr. Shub, who joined Phoenix Children's in 1985, has also devoted his expertise to training future pediatric doctors. A founding member of the University of Arizona College of Medicine-Phoenix, he served for seven years as chair of the Department of Child Health. Dr. Shub was honored to give the school's commencement address in 2018, marking the 10th anniversary of its founding.
Outside of work, Dr. Shub looks forward to visiting his grandchildren every weekend over FaceTime. He also enjoys playing golf with his wife, reading medical literature outside of his field and keeping in touch via Zoom with a longtime group of pediatric GI friends.
Medical School / Education
University of Vermont College of Medicine, Burlington, VT
Residency
(Pediatrics) Duke University Medical Center, Durham, NC
Fellowship
(Pediatric Gastroenterology and Nutrition) Massachusetts General Hospital and Harvard Medical School, Cambridge, MA
Pediatrics, Subspecialty-Pediatric Gastroenterology
American Board of Pediatrics
Gastroenterology
Hepatology
Nutrition
Pediatrics
Inflammatory Bowel Disease
Microvillous Atrophy
Gastric Reflux Disorders
Academic Affiliations
Professor, Clinical Pediatrics, University of Arizona College of Medicine - Phoenix
Executive Chair, Department of Health, University of Arizona College of Medicine - Phoenix
Associate Head, Department of Pediatrics, University of Arizona College of Medicine - Phoenix
Professional Affiliations
Fellow, American Academy of Pediatrics
Phoenix Pediatric Society
American Academy of Pediatrics
Gastroenterology Research Group
Western Society for Pediatric Research
American Gastroenterology Association
American Society for Gastrointestinal Endosurgery
North American Society of Pediatric Gastroenterology, Hepatology and Nutrition
Contributor to Benkov K, Winter H. "Managing Your Child's Crohn's Disease or Ulcerative Colitis" New York. Mastermedia Limited. 1996.
Shub MD. "Section VIII: Gastroenterology," in "Pediatric Hospital Medicine," Perkin RM, Swift JD, Newton D. (Eds.) Philadelphia. Lippincott, Williams, and Wilkins, pp 327-362, 2003.
Shub MD, Walker WA. "Intractable Diarrhea of Infancy," in "Current Pediatric Therapy," Gellis SS, Kagan BM (Eds.) Vol. 10, Philadelphia. Saunders Co., pp 174-175, 1982.
Ulshen MH, Shub MD. "Chronic Diarrhea and Malabsorption Syndromes," in "Gellis & Kagan's Current Pediatric Therapy," Gellis SS, Kagan BM (Eds.) Vol. 13, Philadelphia. WB Saunders Co., pp 222-225, 1990.
Ulshen MH, Shub MD. "Protracted Diarrhea of Infancy," in "Current Pediatric Therapy," Gellis SS, Kagan BM (Eds.) Vol. 13, Philadelphia. WB Saunders Co., pp 186-187, 1990.
Shub MD. "Esophageal Disorders, Gastroesophageal Reflux Disease," in "Pediatric Hospital Medicine," Perkin RM, Swift JD, Newton D. (Eds.) Philadelphia. Lippincott, Williams, and Wilkins, pp 341-344, 2003.
Rayhorn NJ, Shub MD. "Inflammatory Bowel Disease," in "Pediatric Hospital Medicine," Perkin RM, Swift JD, Newton D (Eds.) Philadelphia. Lippincott, Williams, and Wilkins, pp 345-351, 2003.
Shub MD. "Esophageal Burns," in "Pediatric Gastroenterology - A Color Handbook," Pohl J, Jolley C.D, Gelfond D (Eds.) CRC Press, Taylor & Francis Group, LLC, pp 105-113, 2014.
Shub MD, Pang KY, Swann DA, Walker WA. "Age-related Changes in Chemical Composition and Physical Properties of Mucus Glycoproteins from Rat Small Intestine" Biochem J. 1983 Nov 1;215(2):405-11. doi: 10.1042/bj2150405. PMID: 6651768
Hargrove CB, Ulshen MH, Shub MD. "Upper Gastrointestinal Endoscopy in Infants: Diagnostic Usefulness and Safety" Pediatrics. 1984 Nov;74(5):828-31. PMID: 6493878
Shub MD, Ulshen MH, Hargrove CB, Siegal GP, Groben PA, Askin FB. "Esophagitis: A Frequent Consequence of Gastroesophageal Reflux in Infancy" J Pediatr. 1985 Dec;107(6):881-4. doi: 10.1016/s0022-3476(85)80180-3. PMID: 4067745
Groben PA, Siegal GP, Shub MD, Ulshen MH, Askin FB. "Gastroesophageal Reflux and Esophagitis in Infants and Children" Perspect Pediatr Pathol. 1987:11:124-51. PMID: 3299248
Ingebo KR, Rayhorn NJ, Hecht RM, Shelton MT, Silber GH, Shub MD. "Sedation in Children: Adequacy of Two-hour Fasting" J Pediatr. 1997 Jul;131(1 Pt 1):155-8. doi: 10.1016/s0022-3476(97)70141-0. PMID: 9255209
Drewitz DJ, Shub MD, Ramirez FC. "Gastrospirillum Hominis Gastritis in a Child with Celiac Sprue" Dig Dis Sci. 1997 May;42(5):1083-6. doi: 10.1023/a:1018861708647. PMID: 9149067
Pohl JF, Shub MD, Trevelline EE, Ingebo KR, Silber GH, Rayhorn N, Holve S, Hu D. "A Cluster of Microvillous Inclusion Disease in the Navajo Population" J Pediatr. 1999 Jan;134(1):103-6. doi: 10.1016/s0022-3476(99)70380-x. PMID: 9880458
Holve S, Hu D, Shub M, Tyson RW, Sokol RJ. "Liver Disease in Navajo Neuropathy" J Pediatr. 1999 Oct;135(4):482-93. doi: 10.1016/s0022-3476(99)70172-1. PMID: 10518083
El-Serag HB, Gilger MA, Shub MD, Richardson P, Bancroft J. "The Prevalence of Suspected Barrett's Esophagus in Children and Adolescents: A Multicenter Endoscopic Study" Gastrointest Endosc. 2006 Nov;64(5):671-5. doi: 10.1016/j.gie.2006.03.010. PMID: 17055854
Koslap-Petraco M, Shub M, Judelsohn R. "Hepatitis A: Disease Burden and Current Childhood Vaccination Strategies in the United States" J Pediatr Health Care. 2008 Jan-Feb;22(1):3-11. doi: 10.1016/j.pedhc.2006.12.011. PMID: 18174084
Gilger MA, El-Serag HB, Gold BD, Dietrich CL, Tsou VM, McDuffie A, Shub MD. "Prevalence of Endoscopic Findings of Erosive Esophagitis in Children: A Population-based Study" J Pediatr Gastroenterol Nutr. 2008 Aug;47(2):141-6. doi: 10.1097/MPG.0b013e31815eeabe. PMID: 18664864
Erickson RP, Larson-Thome K, Valenzuela RK, Whitaker SE, Shub MD. "Navajo Microvillous Inclusion Disease is Due to a Mutation in MYO5B" Am J Med Genet A. 2008 Dec 15;146A(24):3117-9. doi: 10.1002/ajmg.a.32605. PMID: 19006234
Nguyen DM, El-Serag HB, Shub M, Integlia M, Henderson L, Richardson P, Fairly K, Gilger MA. "Barrett's Esophagus in Children and Adolescents without Neurodevelopmental or Tracheoesophageal Abnormalities: A Prospective Study" Gastrointest Endosc. 2011 May;73(5):875-80. doi: 10.1016/j.gie.2011.01.017. Epub 2011 Feb 26. PMID: 21354565
Galloway D, Pasternak B, Garg S, Shub M. "Multiple Duodenal Ulcers: An Unexpected Finding in Celiac Disease" J Pediatr Gastroenterol Nutr. 2013 Apr;56(4):e21. doi: 10.1097/MPG.0b013e31825040dd. PMID: 22367335
Oatman O, Djedjos C, Olson M, Shub M. "Diabetes Mellitus in Microvillus Inclusion Disease" J Pediatr Gastroenterol Nutr. 2014 Dec;59(6):e50-1. doi: 10.1097/MPG.0b013e3182999b4f. PMID: 23648791
Knowles B, Roland J, Krishnan M, Tyska M, Lapierre L, Dickman P, Goldenring J, Shub M. "Myosin Vb Uncoupling from RAB8A and RAB11A Elicits Microvillus Inclusion Disease" J Clin Invest. 2014 Jul;124(7):2947-62. doi: 10.1172/JCI71651. Epub 2014 Jun 2. PMID: 24892806
Knowles BC, Yu S, Roland JT, Williams JA, Alvarado GS, Lapierre LA, Shub MD, Gao N. Goldenring JR. "Rab11a Regulates Syntaxin 3 Localization and Microvillus Assembly in Enterocytes" J Cell Sci. 2015 Apr 15;128(8):1617-26. doi: 10.1242/jcs.163303. Epub 2015 Feb 11. PMID: 25673875
Shub M. "Therapy of Caustic Ingestions: New Treatment Considerations" Curr Opin Pediatr. 2015 Oct;27(5):609-13. doi: 10.1097/MOP.0000000000000257. PMID: 26196260
Thakkar K, Holub JL, Gilger MA, Shub MD, McOmber M, Tsou M, Fishman DS. "Quality Indicators for Pediatric Colonoscopy: Results from a Multi-center Consortium. Gastrointest Endosc 83(3): 533-541. 2016. doi: 10.1016/j.gie.2015.06.028. Epub 2015 Aug 5.
Miloh T, Shub M, Montes R, Ingebo K, Silber G, Pasternak B. "Text Messaging Effect on Adherence in Children with Inflammatory Bowel Disease" J Pediatr Gastroenterol Nutr. 2017 Jun;64(6):939-942. doi: 10.1097/MPG.0000000000001399. PMID: 27602705
Schlegel C, Weis V, Knowles B, Lapierre L, Martin M, Dickman P, Goldenring JR, Shub M. "Apical Membrane Alterations in Non-intestinal Organs in Microvillus Inclusion Disease" Dig Dis Sci. 2018 Feb;63(2):356-365. doi: 10.1007/s10620-017-4867-5. Epub 2017 Dec 7. PMID: 29218485
Engevik AC, Kaji I, Engevik MA, Meyer AR, Weis VG, Hess MW, Koepsell H, Tyska M, Huber LA, Shub MD, Ameen N, Goldenring JR. "Loss of MYO5B Leads to Reductions in Na+ Absorption With Maintenance of CFTR-Dependent Cl- Secretion in Enterocytes" Gastroenterology. 2018 Dec;155(6):1883-1897.e10. doi: 10.1053/j.gastro.2018.08.025. Epub 2018 Aug 23. PMID: 30144427
Flores S, Carter J, Silber G, Shub M, Timmons Z, Kelleher K, Librizzi J, Morse K. "PCH/PCCN Functional Constipation Pathway" Clinical Pathway - Educational Resource. 2018.
Rating & Reviews
I was pleased with the visit, and the care our Dr. gave us. I appreciated that he took time.
Dr. Shub is the best doctor,he cares about his patients gives you all the information clearly listens to you very professional.
This provider was absolutely amazing, not only did he give us the most information that we were looking for, and was versed in the syndrome that my child has which is rare. He ordered all the testing needed to help find a diagnoses and stated he would connect with the other physicians on my son's team, and had his notes in the portal extremely quickly Along with orders for x-ray and bloodwork. He was extremely friendly and absolutely loved speaking with him.
Dr. Schub has been one of the few Doctors that do care of the needs of my child, he answer all my questions and explain everything in a way I was able to understand and move forward for or next steps, he has really good knowledge and understand our need for our children
Dr. Shub and his care team are the best. They are always very communicative and take the parents into consideration when making any decisions. Definitely recommend him to anyone who needs a GI provider.
I feel my provider does an excellent job of explaining Medical information in terms that are understood by family member's & gives many opportunities for questions or concerns. He also comes across as a very caring. Physician which is reassuring as well!
Dr Shub is a very experienced and knowledgeable doctor, and he is very compassionate and understanding for the Complicated medical issues that my son is facing and that I face as his caretaker. I feel very supported with his team in our corner.
Dr. Shun is always so attentive and truly cares about his patients. He is by far the best doctor my son has been seen by.
Dr Shub seems wonderful, careful, strategic, trustworthy, and very knowledgeable.
The Dr.. was very professional and understanding of my daughter situation,
I had an excellent experience with Dr. Mitchell Shub at Phoenix Children's Gastroenterology. He took the time to thoroughly answer every question we had regarding my son's health concerns. Dr. Shub provided a detailed explanation of my son's reflux issues and his challenges with weight gain, which was incredibly reassuring. His approach was both professional and compassionate, making us feel well-informed and supported throughout our consultation. I would definitely recommend Dr. Shub to my friends and family for anyone in need of a knowledgeable and caring pediatric gastroenterologist.