Early circuit-directed rehabilitation mitigates late-onset sensory hypersensitivity after traumatic brain injury
Led By
Gokul Krishna, PhD
Children’s Neuroscience Grand Rounds
Learning Objectives:
- Recognize the contribution of maladaptive circuit reorganization as a pathophysiological process underlying late-onset neurological deficits after concussive brain injury.
- Evaluate the efficacy of early rehabilitation for lessoning deficit severity and improving circuit function in a well-established model of diffuse axonal injury.
Early pharmacological intervention with gabapentin inhibits traumatic brain injury-mediated synaptogenesis in rats
Student Presenter: Caitlin Hair, PhD
Learning Objectives:
- Describe traumatic brain injury-induced upregulation of thrombospondins implicated in increased-synaptogenesis as a pivotal process in maladaptive circuit reorganization.
- Evaluate the efficacy of early gabapentin treatment to inhibit maladaptive synaptogenesis and improve long-term outcomes.
- Discuss clinical possibilities of prophylactic use of gabapentin after in TBI patients.
Neuropathology and vulnerability to traumatic brain injury in a mouse model of connective tissue disorders
Presented by: Tala Curry, PhD (Candidate)
Learning Objectives:
- Identify that connective tissue disorder (CTD) patient populations may be at risk for elevated severity of symptoms after traumatic brain injury.
- Recognize Marfan Syndrome (CTD) and associated downstream signaling can contribute to neuropathology.