NSGR - Using Stem Cell Models to Study Human Brain Development and Disease - Madeline Andrews, PhD (Arizona State University - Tempe, AZ)

At the end of this presentation, participants should be able to:

• Identify robust features of stem cell models, like forebrain organoids, to study human brain development
• Recognize patient-derived cell lines to assess molecular features underlying neurodevelopmental disorders
• Discuss how dysregulation in mTOR signaling and glucose metabolism impact onset of cortical malformations and neurodevelopmental disorders

About this presenter:

Madeline Andrews, PhD
Assistant Professor
School of Biological and Health Systems Engineering
Arizona State University

Madeline Andrews, PhD is an Assistant Professor in the School of Biological and Health Systems Engineering at Arizona State University. She received her PhD in Neuroscience at UC Los Angeles with Dr. Samantha Butler and her postdoctoral training in Dr. Arnold Kriegstein's lab at UC San Francisco. In her lab at ASU, she develops stem cell models to better reflect molecular features of human brain development. She uses these human models to assess molecular dysregulation in neurological disease states. Her lab is specifically focused on how molecular signaling and metabolism regulate early cell fate, tissue organization, and homeostasis in the cerebral cortex tissue niche.