Clinical trials give some children access to promising new treatments while helping researchers improve care options for future patients. Our neuro-oncology team participates in a variety of studies for children with brain and spinal cord tumors, offering eligible patients additional treatment options close to home.
Open Children’s Oncology Group Studies
ACNS1833
Low-Grade Glioma (LGG)
This study compares two treatment approaches for children with certain low-grade brain tumors. Researchers are evaluating whether a targeted therapy called selumetinib works as well as standard chemotherapy while potentially causing fewer side effects.
Study information
ACNS2021
Localized Non-Germinomatous CNS Germ Cell Tumors
This study evaluates a treatment approach that combines chemotherapy with tailored radiation therapy. The goal is to treat the tumor while limiting radiation exposure whenever possible.
Study information
ACNS2031
Medulloblastoma
This study tests whether a medication called sodium thiosulfate helps protect hearing in children receiving cisplatin chemotherapy. It is also evaluating whether some children with lower-risk medulloblastoma can be treated successfully with less intensive therapy.
Study information
ACNS2321
Central Nervous System Germinomas
This study examines whether chemotherapy followed by reduced-dose radiation therapy can effectively treat germinomas while decreasing long-term treatment side effects.
Study information
ACNS1821
Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG)
This study evaluates the safety and effectiveness of a newer medication called selinexor when used together with radiation therapy for children who have been newly diagnosed with DIPG or high-grade glioma.
Study information
Early-Phase Clinical Trials
MCC23221
Relapsed Medulloblastoma
This study is evaluating whether digoxin, a medication traditionally used to treat heart conditions, can also help treat certain types of recurrent medulloblastoma.
Study information
PEPN2111
Relapsed or Refractory CNS Tumors and Lymphoma
This study is testing an investigational medication called CBL0137 in children whose tumors have returned or have not responded to previous treatment. Researchers are evaluating its safety and looking for signs that it may help control tumor growth.
Study information
PEPN2415
Newly Diagnosed High-Grade Glioma and Diffuse Midline Glioma
This study is evaluating a new investigational medication called AZD1390 when combined with radiation therapy. Researchers hope the treatment may improve the effectiveness of radiation for aggressive brain tumors.
Study information
CONNECT2110
DIPG and H3K27-Altered High-Grade Gliomas
This study is evaluating ACT001, an investigational targeted therapy for children and adolescents with newly diagnosed or recurrent DIPG and related high-grade brain tumors. Researchers are studying how well the treatment works and its potential side effects.
Study information
DAY101 (LOGGIC/FIREFLY-2)
Pediatric Low-Grade Glioma
This study is comparing the targeted therapy tovorafenib with standard treatment options for children who need their first systemic treatment for low-grade glioma. Researchers are evaluating whether the targeted therapy can improve outcomes while maintaining quality of life.
Study information