About Lindsey M. Hoffman, DO

Lindsey Hoffman, DO, MS, specializes in pediatric neuro-oncology. She serves as director of both the Cancer Predisposition Program and the Neuro-Oncology Program at the Center for Cancer and Blood Disorders at Phoenix Children's.

Dr. Hoffman was drawn to work at Phoenix Children's because of the diverse patient population the hospital serves.

After earning a Master of Science degree in Human Genetics from Tulane University in New Orleans, Dr. Hoffman went on to obtain a Doctor of Osteopathic Medicine degree from Kansas City University of Medicine & Biosciences in Kansas City.

She holds board certifications in both general pediatrics and pediatric hematology/oncology through the American Board of Pediatrics.

Dr. Hoffman is a member of numerous professional affiliations, including the American Academy of Pediatrics, American Society of Pediatric Hematology/Oncology, and Society of Neuro-Oncology. She serves as Chair of the International DIPG/DMG Registry and Co-Chair for the Response Assessment in Pediatric Neuro-Oncology (RAPNO) Committee.

To further her field, Dr. Hoffman is heavily involved in research that centers around improving the understanding, diagnosis and treatment of childhood cancer. She has authored numerous publications, including book chapters, articles and peer-reviewed abstracts and has presented at multiple regional, national and international conferences.

Dr. Hoffman provides personalized, evidence-based care. She collaborates with her patients and their families to implement a plan that serves them best.

Outside her practice, Dr. Hoffman volunteers with the "Feed My Starving Children" organization. In her free time, she enjoys outdoor activities and traveling with her children.

Medical School / Education

Kansas City University of Medicine & Biosciences, Kansas City, MO


(General Pediatrics) Baylor College of Medicine, Houston, TX


(Pediatric Neuro-Oncology) Cincinnati Children's Hospital Medical Center, Cincinnati, OH

(Pediatric Hematology/Oncology/Bone Marrow Transplant) University of Colorado Denver, Aurora, CO

General Pediatrics, Pediatric Hematology/Oncology

American Board of Pediatrics

Professional Affiliations

American Academy of Pediatrics

American Society of Pediatric Hematology/Oncology

Society of Neuro-Oncology

Chair, International DIPG/DMG Registry

Co-Chair, Response Assessment in Pediatric Neuro-Oncology (RAPNO) Committee

Khan S, Solano-Paez P, Suwal T, Lu M, Al-Karmi S, Ho B, Mumal I, Shago M, Hoffman LM, Dodgshun A, Nobusawa S, Tabori U, Bartels U, Ziegler DS, Hansford JR, Ramaswamy V, Hawkins C, Dufour C, Andre N, Bouffet E, Huang A, Rare Brain Tumor Registry. Lancet Child Adolesc Health 2021 Nov;5(11):800-813.

DeSisto J, Lucas JT Jr, Xu K, Donson A, Lin T, Snaford B, Wu G, Tran QT, Hedges D, Hsu CY, Armstrong GT, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Schuller U, Hoffman LM, Dorris K, Mulcahy Levy J, Hankinson TC, Handler M, Liu A, Foreman N, Vibhakar R, Jones K, Allen S, Zhang J, Baker SJ, Merchant TE, Orr BA, Green AL. Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targets. Nature Communications 2021 Sep;12(1):5531.

Self C, Suttman A, Wolf Schneider K, Hoffman L. Lynch syndrome: further defining the pediatric spectrum. Cancer Genet 2021 Jul 25;258-259:37-40.

Fleming JM, Ross S, Hoffman LM, Coughlin R, Crombleholme TM, Mong DA, Hilden J, Maloney K, Tan GM. Pediatric mediastinal mass algorithm: a quality improvement initiative to reduce time from presentation to biopsy. Pediatr Anaesth. 2021 Aug;31(8):885-893.

Graham RT, Abu-Arja MH, Stanek JR, Cappellano A, Coleman C, Chi S, Cooney T, Dhall G, Ellen JG, Finlay JL, Fisher MJ, Friedman GK, Gajjar A, Gauvain K, Hoffman LM, Hukin J, Lucas JT Jr, Mueller S, Navalkele P, Ronsley R, Tinkle C, Villeneuve S, Yeo KK, Su JM, Margol A, Gottardo NG, Allen J, Packer R, Bartels U, Abdelbaki MS. Multi-institutional analysis of treatment modalities in basal ganglia and thalamic germinoma. Pediatr Blood Cancer. 2021 Oct;68(10):e29172.


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Phoenix, AZ 85016

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Doctor Hoffman has been with us since diagnosis in 2021, and she is amazing.