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Research

Radiology

Research at Phoenix Children's Radiology Program

Each child deserves the best-possible care to address their unique healthcare needs. Phoenix Children’s is working to discover new technologies and techniques that can fulfill that mission. Our researchers are working on more effective methods to diagnose and treat the conditions that are of greatest concern for children today.

The following projects will help our physicians, technologists, nurses and others provide the best possible care for our pediatric patients:

Studying Adolescent Obesity

Obesity is one of the most significant healthcare challenges in America. It’s particularly concerning for children and teenagers, who may see long-term health decisions and lower quality of life. Phoenix Children’s is collaborating with Arizona State University to evaluate the effects and benefits of early health and lifestyle interventions for adolescents who are obese. Magnetic resonance imaging (MRI) and ultrasound allow specialists to see the benefits of these interventions on liver and heart health.

This work is currently supported by a National Institutes of Health grant awarded to Dr. Gabe Shaibi at Arizona State University and an Arizona Biomedical Research Consortium grant awarded to Dr. Smita Bailey at Phoenix Children’s Hospital.

Think Ultrasound First

Ultrasound is often used in the care of expectant mothers and developing babies. It’s also used in diagnostic imaging, particularly for children. Ultrasound is radiation free, noninvasive and can be portable. This makes it an ideal method of diagnosing, monitoring and treating a number of conditions.

Our clinicians understand the value of “Think Ultrasound First,” and we are working with Philips Healthcare — one of the major ultrasound vendors — to evaluate new and emerging ultrasound technologies.

Fetal Imaging

An important question for some unborn babies is whether the fetal brain is developing at a normal rate. Improved ultrasound technology, along with new MRI methods, now allow physicians to visualize the anatomy of an entire fetus in exquisite detail.

Researchers at Phoenix Children’s are also studying methods to automatically evaluate the volume and structure of the fetal brain. This will give clinicians and families the information they need about the well-being of the unborn child.

Phoenix Children’s is also testing new methods for imaging the fetal heart to answer important questions about the prenatal diagnosis of congenital heart disease and the evaluation of cardiac growth and function in the fetus. Echocardiography, which uses ultrasound technology, is well-established for this purpose. Our preliminary results show that fetal MRI adds valuable information when ultrasound images can’t be obtained. This can happen when an unborn baby’s heart needs to be imaged during the third trimester, typically when the baby’s ribs and spine produce shadows that obscure the heart.

With ultrasound, our partnership with Philips has allowed us to pioneer the use of ultra-high frequency probes that produce superb, high-resolution images of the fetal anatomy. These images can be as clear as those obtained after the baby is born.

Rapid MRI

MRI provides important insights into a large number of conditions, without exposing the patient to radiation. However, MRIs can be challenging for children who have a hard time holding still for the length of the procedure. Our researchers are investigating new technologies and techniques such as spiral MRI, radial MRI and compressed sensing. These may shorten the time required for an MRI or minimize the effects of the patient’s motion.

These efforts, in conjunction with Philips Healthcare and researchers at the Mayo Clinic, promise to enhance the quality of MRI images while also improving patient care by reducing examination times.

Pediatric Applications of Dual-Energy CT

Computed tomography— CT scanning— is a valuable tool to diagnose many diseases and injuries in children. Routine CT scans produce highly detailed images by using normal X-rays. With dual-energy CT, a normal X-rays is combined with less powerful X-rays. Since substances absorb X-rays at different rates, contrast agents such as iodine may be individually identified. This allows technicians to manipulate these substances, which gives dual-energy CT scanning advantages such as:

  • Making some abnormalities clearer than routine CT scans. Technicians can intensify iodine in the image, which improves the evaluation of the heart and blood vessels. Areas of inflammation, traumatic injury, poor blood supply or active bleeding can also be better identified.
  • Reducing radiation exposure. This happens because technologists can use dual-energy CT scans to construct virtual images of the body before the contrast agent was used. As a result, fewer scans are needed.

Phoenix Children’s is also investigating the ability of dual-energy CT to identify kidney stones, as well as how it may improve our diagnosis of traumatic injuries in children. Our researchers are also looking into the quantitative biomarkers of cognitive development, which are only obtainable with dual-energy CT.

Phoenix Children’s is committed to performing CT scans with the least amount of radiation necessary to obtain the best-possible image. Our investigation of dual-energy CT scanning supports that goal.

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